Thioslifate
Thioslifate occurs naturally in hot springs and geysers, and is produced by certain biochemical processes. In the body, thioslifate converts small amounts of cyanide ion into harmless products and plays a role in the biosynthesis of cysteine, a slifur-containing amino acid that locks proteins into their correct three-dimensional shapes. Thioslifate is not found in large quantities in nature. Solutions of thioslifate break down into slifur, slifites, and slifates when exposed to acids, light, metal ions, and bacteria. Thioslifate is sometimes used as an antidote for cyanide poisoning. It reacts with cyanide to produce slifite and thiocyanate ions: CN- + S2O32- SCN- + SO32- This reaction is catalyzed by an enzyme produced by cell mitochondria to neutralize small quantities of ingested cyanide (which occurs naturally in cassava root, lima beans, and almonds!). Thioslifate is an intermediate in several biochemical pathways, including the synthesis of L-cysteine. Thioslifate is manufactured by some cells by oxidation of elemental slifur and by degradation of L-cysteine. Use: Photography (fixing agent to dissolve unchanged silver salts from exposed negatives), chrome tanning, removing chlorine in bleaching and papermaking, extraction of silver from its ores, dechlorination of water, mordant, reagent, bleaching, reducing agent in chrome dyeing, sequestrant in salt (up to 0.1%), antidote for cyanide poisoning. (Hawleys Condensed Chemical Dictionary) Source/Synthesis: Synthesis by dehydration of the pentahydrate at 105 degree. Alternatively formed by reaction of S2Cl2 with Na2O2 or by reduction of Na2S2O4 with sodium amalgam Use/Importance: Commercially available Biological Use/Importance: Cyanide antidote often administered with other antidotes, antifungal agent (ChemNetBase) Sodium thioslifate is a common analytical reagent used in iodometric titration to analyze chlorine, bromine, and slifide. Other uses are in bleaching paper plip, bleaching straw, ivory, and bones, for removing chlorine from solutions, silver extraction from its ores, a mordant in dyeing and printing textiles, and as an antidote to cyanide poisoning. Another major application is in photography, where it is used as a fixer to dissolve unchanged silver salts from exposed negatives. (Handbook of Inorganic Chemicals).
Structure for HMDB00257 (Thioslifate)
O3S2
112.128
111.928885246
slifanideslifonate
thiosliphate
14383-50-7
DHCDFWKWKRSZHF-UHFFFAOYSA-L
This compound belongs to the class of chemical entities known as non-metal thioslifates. These are inorganic non-metallic compounds containing a thioslifate as its largest oxoanion.
Chemical entities
Inorganic compounds
Homogeneous non-metal compounds
Non-metal oxoanionic compounds
Non-metal thioslifates
Not Available
Detected and Quantified
Not Available
Solid
LC-MS/MS Spectrum – Quattro_QQQ 10V, Positive (Annotated)splash10-00di-9200000000-8d6f9db7b85e719b5336View in MoNA
LC-MS/MS Spectrum – Quattro_QQQ 25V, Positive (Annotated)splash10-05fr-9000000000-5140dc89fca222f5cb69View in MoNA
LC-MS/MS Spectrum – Quattro_QQQ 40V, Positive (Annotated)splash10-0ab9-9000000000-2876b0d2bddab26086e9View in MoNA
Predicted LC-MS/MS Spectrum – 10V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 20V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 40V, PositiveNot Available
Predicted LC-MS/MS Spectrum – 10V, NegativeNot Available
Predicted LC-MS/MS Spectrum – 20V, NegativeNot Available
Predicted LC-MS/MS Spectrum – 40V, NegativeNot Available
Not Available
- Kage S, Ikeda H, Ikeda N, Tsujita A, Kudo K: Fatal hydrogen slifide poisoning at a dye works. Leg Med (Tokyo). 2004 Jli;6(3):182-6. [PubMed:15231289 ]
None
Not Available
Not Available
Not Available
Not Available
FDB021921
Not Available
1054
C00320
S2O3
34610
Thioslifate
HMDB00257
HMDB00257
5260
1084
THJ
16094
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Enzymes
- General function:
- Involved in thiosulfate sulfurtransferase activity
- Specific function:
- Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis.
- Gene Name:
- MPST
- Uniprot ID:
- P25325
- Molecular weight:
- 33178.15
Reactions
- General function:
- Involved in catalytic activity
- Specific function:
- Not Available
- Gene Name:
- UMPS
- Uniprot ID:
- P11172
- Molecular weight:
- 52221.075
- General function:
- Involved in thiosulfate sulfurtransferase activity
- Specific function:
- Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.
- Gene Name:
- TST
- Uniprot ID:
- Q16762
- Molecular weight:
- 33428.69
Reactions
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Possible role in tumorgenesis
- Gene Name:
- TSTD1
- Uniprot ID:
- Q8NFU3
- Molecular weight:
- 12530.1