Name :
IL-18RAP Protein
Description :
IL-18RAP, also known as IL-18Rβ or IL-1R7, is component of IL-18 receptor complex and its interactions with IL-18R1 mediate signal transduction initiated by IL-18 although it does not directly bind IL-18 in vitro.
Species :
Cynomolgus
Uniprotkb :
HEK293
Tag :
C-His
Synonyms :
IL-18RAcP, IL-1R7, IL-18R-β, IL-18Rbeta, IL18RAP, IL18RB, IL-1R-7, IL-18R-beta, CD218b, ACPL, CDw218b, IL-1RAcPL, IL-18Rβ
Construction :
Recombinant Cynomolgus IL-18RAP Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Phe20-Arg356.[Accession |A0A2K5VDC3]
Protein Purity :
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight :
The protein has a predicted MW of 39.5 kDa. Due to glycosylation, the protein migrates to 60-68 kDa based on Tris-Bis PAGE result.
Endotoxin :
Less than 1EU per μg by the LAL method.
Formulatione :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage :
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background :
IL-18RAP, also known as IL-18Rβ or IL-1R7, is component of IL-18 receptor complex and its interactions with IL-18R1 mediate signal transduction initiated by IL-18 although it does not directly bind IL-18 in vitro.
References and Literature :
1. Hedl M, et al. The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways. J Immunol. 2014;192(12):5924-5932. doi:10.4049/jimmunol.1302727 2. Zhu J, et al. Association of the interleukin-18 receptor 1 and interleukin-18 receptor accessory protein polymorphisms with the risk of esophageal cancer. Biomed Rep. 2016 Feb;4(2):227-235.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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