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The aim of this brief critique is always to trigger a much more crucial evaluation of scientific evidence TLR8 drug current in literature on potential hepatotoxicity of Curcuma longa. The revision of sources could be against the latest trend that blames this well-known spice broadly applied for centuries. Curcuma longa has been utilized throughout human history for many purposes as a result of its wide selection of biological activity (Sharifi-Rad et al., 2020). Curcumin was identified to be the primary active component from the extract from the rhizome, referred to as turmeric. Curcumin could be the ingredient accountable for the effects of turmeric as a drug in its long history of use in standard Asian medicine for any wide wide variety of disorders. The Compendium of PPARĪ³ Compound Sushruta, the foundational text of Ayurveda dating to 250 BCE (Joshi et al., 2017), recommends an ointment containing turmeric, Curcuma longa powdered, to relieve the effects of poisoned food. It’s not surprising, therefore, that curcumin is at present sold as a dietary supplement and that various clinical trials are ongoing to evaluate curcumin activity. Inside the last decade a large number of reports happen to be published on the beneficial effects of curcumin (Barchitta et al., 2019) and it has been repeatedly claimed that this all-natural item is efficient and safe for the prevention and remedy of various diseases (Abd El-Hack et al., 2021). Furthermore, curcumin has been broadly studied for its antioxidant, anti-inflammatory, and wound-healing effects (Menon and Sudheer, 2007; Shirban et al., 2021). This natural polyphenol is regarded by some authors as a “wonder drug of life” (Gera et al., 2017) and it’s categorized as a “generally recognized as safe” (GRAS) material, using a stable metabolism and low toxicity (Nelson et al., 2017). More than recent years, food supplements containing Curcuma longa have been extensively used by an escalating number of customers and there’s accumulating proof that curcumin might not be so effective and secure. Quite a few reports happen to be issued that described the circumstances of highly probable drug-induced autoimmune hepatitis (DIAIH) ascribed to ingestion of Curcuma longa dietary supplement (Philips et al., 2020). That is, in contrast with all the use, due to the fact ancient times, of Curcuma longa, as hepatoprotective (Rahmani et al., 2016; Tung et al., 2017; Peng et al., 2018) and for the therapy of digestive tract challenges (Gera et al., 2017). Additionally, in literature it can be reported that curcumin could stop oxidative stress-related liver disorder causing a series of metabolic reactions as i) decreasing the levels of alanine transaminase (ALT), aspartase transaminase (AST), and alkaline phosphatase (ALP). ii) It increases the expression of glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) whilst further iii) decreasing NO production and inhibiting ROS formation (Farzaei et al., 2018). The most typical substance related with Curcuma longa in its use as meals supplement is piperine from Piper nigrum L. Black pepper (Piper nigrum L.) is the most used specie of pepper and it has discovered a worldwide use as a spice. Its history of use in conventional medicine is thousands of years old, being pointed out in Ayurvedic medicine treatie