Ters, CSIR-HRDC Campus Sector 19, Kamala Nehru Nagar, Ghaziabad 201002, India Correspondence: [email protected]; Tel.: +61-3-9925-Citation: Jakku, R.K.; Mirzadeh, N.; Priv , S.H.; Reddy, G.; Vardhaman, A.K.; Lingamallu, G.; Trivedi, R.; Bhargava, S.K. TetraphenylethyleneSubstituted Bis(thienyl)imidazole (DTITPE), An Efficient Molecular Sensor for the Detection and Quantification of Fluoride Ions. Chemosensors 2021, 9, 285. https:// doi.org/10.3390/chemosensors9100285 Academic Editors: Valerio Vignoli and Enza PanzardiAbstract: Fluoride ion plays a pivotal role within a array of biological and chemical applications however excessive exposure may cause severe kidney and gastric troubles. A simple and selective molecular sensor, 4,5-di(thien-2-yl)-2-(4-(1,two,2-triphenylvinyl)-phenyl)-1H-imidazole, DTITPE, has been synthesized for the detection of fluoride ions, with detection limits of 1.37 10- 7 M and 2.67 10-13 M, determined by UV-vis. and fluorescence spectroscopy, respectively. The variation within the optical properties on the molecular sensor inside the presence of fluoride ions was explained by an intermolecular charge transfer (ICT) method involving the bis(thienyl) and tetraphenylethylene (TPE) moieties upon the formation of a N-H–F- hydrogen bond with the imidazole proton. The sensing mechanism exhibited by DTITPE for fluoride ions was confirmed by 1 H NMR spectroscopic research and density functional theory (DFT) calculations. Test strips coated together with the molecular sensor can detect fluoride ions in THF, undergoing a colour change from white to yellow, which could be observed together with the naked eye, showcasing their prospective real-world application. Keyword phrases: bis(thienyl) imidazole; tetraphenylethylene; molecular sensor; fluoride anion; fluorescenceReceived: 23 July 2021 Accepted: 28 September 2021 Published: 6 OctoberPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.1. Introduction The detection and recognition of anionic analytes has created into an incredibly active research field in recent years [14]. Anions play a critical part in a selection of biological and chemical processes, and their detection, even at extremely low concentrations, has been the motivation for continuous improvement in sensor improvement more than the final couple of decades [15,16]. In line with the prior literature, the probable toxic dose (PTD) of fluoride was defined at five mg/kg of physique mass. The PTD is the minimal dose that could trigger significant and life-threatening indicators and symptoms which call for instant remedy and hospitalization [17]. The fluoride anion, possessing the smallest ionic radii, hard Lewis simple nature and high charge density, has emerged as an appealing topic for sensor style as a consequence of its PF 05089771 Epigenetics association using a wide selection of organic, medicinal, and technological procedures. Additionally, fluoride ions play a significant part in dental wellness [18] and has been utilized for the therapy of osteoporosis [191] and for military utilizes, like the refinement of uranium for nuclear weapons [22]. It is readily absorbed by the human bodyCopyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is definitely an open access post distributed beneath the terms and circumstances with the Inventive Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ four.0/).Chemosensors 2021, 9, 285. https://doi.org/10.3390/Infigratinib MedChemExpress chemosensorshttps://www.mdpi.com/journal/chemosensorsChemosensors 20.