Thu. Feb 22nd, 2024

ical Oncology, Leiden University Medical Center, Leiden, Netherlands; 4Department of Clinical Epidemiology, Leiden University Health-related Center, Leiden, Netherlands Background: Individuals with osteosarcoma and Ewing sarcoma are regarded to possess a higher threat of venous thromboembolism (VTE), even though the exact incidence is understudied. Aims: To study the incidence of VTE and main bleeding (MB) in these sufferers. Techniques: We performed a chart evaluation in individuals treated for osteosarcoma (OS) or Ewing sarcoma (ES) in our hospital amongst 1980 and 2018. The study was authorized by the Institutional Assessment Board. Patient charts have been scrutinized for patient and tumor characteristics, and outcome events, the latter adjudicated by an independent expert. Cumulative incidences have been estimated making use of Kaplan-Meier and cumulative incidence competing danger (CICR) process. Multivariable time-dependent Cox models had been utilised to ascertain the association between outcome events and mortality. Outcomes: Baseline qualities of 520 osteosarcoma and 165 Ewing sarcoma individuals are shown in Table 1. VTE occurred in 65 OS patients (13 ) and 11 ES sufferers (6.7 ), MB in 31 OS patients (six.0 ) and 9 ES patients (five.5 ). Adjusted cumulative incidences for VTE and MB at 3, six, 9, 12 and 24 months are presented in Table 2. One of the most frequent VTE presentation was arm vein thrombosis (32 and 45 in OS and ES, respectively), mainly D3 Receptor Antagonist list associated with central venous catheters (CVC; in 18/21 OS sufferers and 5/5 ES patients). In the 31 MB complications in osteosarcoma patients, 13 patients have been known to make use of prophylactic or therapeutic anticoagulants (42 ). The majority of MBs (84 in OS, 78 in ES) have been bleedings within metastases or rebleeds just after surgery. In osteosarcoma, VTE and MB were each related with all-cause mortality (adjusted HRs 1.9 (95 CI 1.3.7) and 3.three (95 CI 2.1.1) respectively), whereas this association was only present for MB in Ewing sarcoma (adjusted HR 2.9 (95 CI 1.0.1)).ABSTRACT809 of|TABLE 1 Baseline traits of osteosarcoma and Ewing sarcoma patientsBaseline characteristics Variety of sufferers Osteosarcoma 520 Ewing sarcomaAge at diagnosis – years Imply (+/- SD) Variety Gender – no ( ) Male FemalePresence of distant metastases at time of diagnosis – no ( )32 (19) 3.523 (13) 1.2288 (55) 232 (45)107 (21)113 (69) 52 (32)50 (30)Tumor grade – no ( ) High grade sarcoma Low grade sarcoma Intermediate grade Undefined Presence of CVC – no ( ) Yes No UnknownPatients died – no ( ) Median follow-up time in months – IQR453 (87) 40 (7.7) ten (1.9) 17 (three.3)NA NA NA NA394 (76) 91 (18) 35 (six.7)257 (49) 60 (2242)152 (92) three (two) ten (six.1)88 (53) 42 (1924)SD: typical deviation; no: number; CVC: central venous H4 Receptor Agonist Synonyms catheter; IQR: interquartile variety; NA: not availableTABLE 2 Adjusted cumulative incidences of venous thrombotic complications and major bleeding events in osteosarcoma sufferers and Ewing sarcoma sufferers Osteosarcoma VTE (95 CI)5.two (three.5.3) six.7 (four.8.1) 7.5 (5.40) 8.3 (six.11) 8.eight (6.61)Index date: date of histological diagnosis of OS or ES three months 6 months 9 months 12 months 24 monthsEwing sarcoma VTE (95 CI)1.eight (0.50.eight) 1.eight (0.50.8) four.2 (1.9.1) six.1 (3.10) 6.7 (3.51)Osteosarcoma MB (95 CI)1.two (0.48.4) 2.3 (1.3.9) two.five (1.4.1) 3.3 (2.0.1) four.0 (two.6.0)Ewing sarcoma MB (95 CI)0 0.61 (0.06.1) 0.61 (0.06.1) 1.2 (0.24.0) two.five (0.81.eight)OS: osteosarcoma; ES: Ewing sarcoma; VTE: venous thromboembolism; MB: major bleeding; CI: self-assurance interval Adjusted cumulative incidence: cu