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C dysfunction in obesity and metabolic syndrome. Can. J. Neurol. Sci. 2008, 35, 310. Rogge, M.M. The function of impaired mitochondrial lipid oxidation in obesity. Biol. Res. Nurs. 2009, 10, 35673. Chanseaume, E.; Morio, B. Prospective mechanisms of muscle mitochondrial dysfunction in aging and obesity and cellular consequences. Int. J. Mol. Sci. 2009, ten, 30624. Zorzano, A.; Hernandez-Alvarez, M.I.; Palacin, M.; Mingrone, G. Alterations inside the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1 or PGC-1 and mitofusin two in skeletal muscle in kind two diabetes. Biochim. Biophys. Acta 2010, 1797, 1028033. Wilson, L.; Yang, Q.; Szustakowski, J.D.; Gullicksen, P.S.; Halse, R. Pyruvate induces mitochondrial biogenesis by a PGC-1 -independent mechanism. Am. J. Physiol. Cell Physiol. 2007, 292, C1599 1605. Owen, L.; Sunram-Lea, S.I. Metabolic agents that improve ATP can improve cognitive functioning: A overview with the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine. Nutrients 2011, three, 73555. Ivy, J.L.; Cortez, M.Y.; Chandler, R.M.; Byrne, H.K.; Miller, R.H. Effects of pyruvate around the metabolism and insulin resistance of obese Zucker rats. Am. J. Clin. Nutr. 1994, 59, 33137. Das, U.N. Pyruvate is an endogenous Bradykinin Receptor Source anti-inflammatory and anti-oxidant molecule. Med. Sci. Monit. 2006, 12, RA79 A84. Bunton, C.A. Oxidation of a-diketones and a-keto-acids by hydrogen peroxide. Nature 1949, 163, 444.Nutrients 2013,21. Dobsak, P.; Courderot-Masuyer, C.; Zeller, M.; Vergely, C.; Laubriet, A.; Assem, M.; Eicher, J.C.; Teyssier, J.R.; Wolf, J.E.; Rochette, L. Antioxidative properties of pyruvate and protection from the ischemic rat heart for the duration of cardioplegia. J. Cardiovasc. Pharmacol. 1999, 34, 65159. 22. Cruz, R.J., Jr.; Harada, T.; Sasatomi, E.; Fink, M.P. Effects of ethyl pyruvate and also other alpha-keto carboxylic acid derivatives within a rat model of multivisceral ischemia and reperfusion. J. Surg. Res. 2011, 165, 15157. 23. Olek, R.A.; Ziolkowski, W.; Kaczor, J.J.; Wierzba, T.H.; Antosiewicz, J. Greater hypochlorous acid scavenging PPAR review activity of ethyl pyruvate when compared with its sodium salt. Biosci. Biotechnol. Biochem. 2011, 75, 50004. 24. Johansson, A.S.; Johansson-Haque, K.; Okret, S.; Palmblad, J. Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation towards the NF-kappaB pathway. Br. J. Pharmacol. 2008, 154, 1318326. 25. Kim, J.B.; Yu, Y.M.; Kim, S.W.; Lee, J.K. Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection within the postischemic brain. Brain Res. 2005, 1060, 18892. 26. Zeng, J.; Liu, J.; Yang, G.Y.; Kelly, M.J.; James, T.L.; Litt, L. Exogenous ethyl pyruvate versus pyruvate through metabolic recovery soon after oxidative strain in neonatal rat cerebrocortical slices. Anesthesiology 2007, 107, 63040. 27. Fedeli, D.; Falcioni, G.; Olek, R.A.; Massi, M.; Cifani, C.; Polidori, C.; Gabbianelli, R. Protective impact of ethyl pyruvate on msP rat leukocytes broken by alcohol intake. J. Appl. Toxicol. 2007, 27, 56170. 28. Olek, R.A.; Ziolkowski, W.; Flis, D.J.; Fedeli, D.; Fiorini, D.; Wierzba, T.H.; Gabbianelli, R. The effect of ethyl pyruvate supplementation on rat fatty liver induced by higher fat eating plan. J. Nutr. Sci. Vitaminol. (Tokyo) 2013, in press. 29. Ellman, G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82, 707. 30. Lowry, O.H.; Rosebrough, N.J.; Farr, A.L.; Randall, R.J. Protein measurement together with the Folin phenol reagent. J. Biol. Chem. 1951, 1.