Tue. Feb 27th, 2024

Mmunol. Right now 11, 13742 25. Albert, L. J., and Inman, R. D. (1999) Molecular mimicry
Mmunol. Nowadays 11, 13742 25. Albert, L. J., and Inman, R. D. (1999) Molecular mimicry and autoimmunity. N. Engl. J. Med. 341, 2068 074 26. May possibly, E., Dorris, M. L., Satumtira, N., Iqbal, I., Rehman, M. I., Lightfoot, E., and Taurog, J. D. (2003) CD8 T cells are certainly not important to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J. Immunol. 170, 1099 105 27. Popov, I., Dela Cruz, C. S., Barber, B. H., Chiu, B., and Inman, R. D. (2001) The impact of an anti-HLA-B27 immune response on CTL recognition of Chlamydia. J. Immunol. 167, 3375382 28. Popov, I., Dela Cruz, C. S., Barber, B. H., Chiu, B., and Inman, R. D. (2002) Breakdown of CTL tolerance to self HLA-B2705 induced by exposure to Chlamydia trachomatis. J. Immunol. 169, 40334038 29. Fourneau, J. M., Bach, J. M., van Endert, P. M., and Bach, J. F. (2004) The elusive case for any function of mimicry in autoimmune illnesses. Mol. Immunol. 40, 1095102 30. Bachmaier, K., Neu, N., de la Maza, L. M., Pal, S., Hessel, A., and Penninger, J. M. (1999) Chlamydia infections and heart illness linked by way of HSP105 Formulation antigenic mimicry. Science 283, 1335339 31. Swanborg, R. H., Boros, D. L., Whittum-Hudson, J. A., and Hudson, A. P. (2006) Molecular mimicry and horror autotoxicus: do chlamydial infections elicit autoimmunity Specialist Rev. Mol. Med. 8, 13 32. Kuon, W., Holzhutter, H. G., Appel, H., Grolms, M., Kollnberger, S., Traeder, A., Henklein, P., Weiss, E., Thiel, A., Lauster, R., Bowness, P., Radbruch, A., Kloetzel, P. M., and Sieper, J. (2001) Identification of HLA-B27restricted peptides from the Chlamydia trachomatis proteome with feasible relevance to HLA-B27-associated diseases. J. Immunol. 167, 4738 4746 33. Appel, H., Kuon, W., Kuhne, M., Wu, P., Kuhlmann, S., Kollnberger, S., Thiel, A., Bowness, P., and Sieper, J. (2004) Use of HLA-B27 tetramers to determine low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis. Arthritis Res. Ther. 6, R521 534 34. Wooldridge, L., Ekeruche-Makinde, J., van den Berg, H. A., Skowera, A., Miles, J. J., Tan, M. P., Dolton, G., Clement, M., Llewellyn-Lacey, S., Price, D. A., Peakman, M., and Sewell, A. K. (2012) A single autoimmune T cell receptor recognizes a lot more than a million unique peptides. J. Biol. Chem. 287, 1168 177 35. Karunakaran, K. P., Rey-Ladino, J., Stoynov, N., Berg, K., Shen, C., Jiang,
Protein acetylation was originally recognized as an important post-translational IRAK4 Species modification of histones in the course of transcription and DNA repair [1]. Recently, nonetheless, the arena of acetylation has been extended to consist of non-histone proteins, specifically those involved inside the approach of DNA double strand break (DSB) repair [2]. In reality, it has been recently demonstrated that acetylation regulates the crucial DNA damage response kinases ATM and DNA-PKcs [2,4], as well as a plethora of DNA repair variables which includes NBS1, Ku70, and p53 [3,6]. These evidences tend to assistance a pivotal role for acetylation in the approach of DNA harm response and repair–ostensibly through facilitating the recognition and signaling of DNA lesions, too as orchestrating protein interactions to recruit activities necessary within the process in the repair. Particularly, acetylation is crucial within the activation of DNA damage response pathways [2,4]. In spite of those advances, precise functional roles of acetylation on the most non-histone DNA repair proteins are nevertheless elusive. Current investigation suggests that this covalent protein post-translational modification could a.