Vidence that lglutamate is a neurotransmitter of main vagal afferent nerve fibers. Brain Res. 1981;230:283sirtuininhibitor3. 16. Groves DA, Bowman EM, Brown VJ. Recordings from the rat locus coeruleus during acute vagal nerve stimulation within the anaesthetised rat. Neurosci Lett. 2005;379:174sirtuininhibitor. 17. Loy R, Koziell DA, Lindsey JD, Moore RY. Noradrenergic innervation with the adult rat hippocampal formation. J Comp Neurol. 1980;189:699sirtuininhibitor10.Liu et al. J Transl Med (2016) 14:Web page 12 of18. Loughlin SE, Foote SL, Fallon JH. Locus coeruleus projections to cortex: topography, morphology and collateralization. Brain Res Bull. 1982;9:287sirtuininhibitor4. 19. Feeney DM, Westerberg VS. Norepinephrine and brain damage: alpha noradrenergic pharmacology alters functional recovery just after cortical trauma. Can J Psychol. 1990;44:233sirtuininhibitor2. 20. Dam M, Tonin P, De Boni A, Pizzolato G, Casson S, Ermani M, et al. Effects of fluoxetine and maprotiline on functional recovery in post stroke hemiplegic individuals undergoing rehabilitation therapy. Stroke. 1996;27:1211sirtuininhibitor. 21. McGaugh JL. Memory century of consolidation. Science. 2000;287:248sirtuininhibitor1. 22. Clark KB, Smith DC, Hassert DL, Browning RA, Naritoku DK, Jensen RA. Posttraining electrical stimulation of vagal afferents with concomitant vagal efferent inactivation enhances memory storage processes within the rat. Neurobiol Study Mem. 1998;70:364sirtuininhibitor3. 23. Clark KB, Naritoku DK, Smith DC, Browning RA, Jensen RA. Enhanced rec ognition memory following vagus nerve stimulation in human subjects. Nat Neurosci. 1999;two(1):94sirtuininhibitor. 24. Beekwilder JP, Beems T. Overview of the clinical applications of vagus nerve stimulation. J Clin Neurophysiol. 2010;27:130sirtuininhibitor. 25. Bohotin C, Scholsem M, Multon S, Martin D, Bohotin V, Schoenen J. Vagus nerve stimulation in awake rats reduces formalininduced nociceptive behaviour and fosimmunoreactivity in trigeminal nucleus caudalis. Pain. 2003;101:3sirtuininhibitor2. 26. George MS, Nahas Z, Bohning DE, Kozel FA, Anderson B, Chae JH, et al. Vagus nerve stimulation therapy: a investigation update. Neurology. 2002;59:S56sirtuininhibitor1. 27. Sjogren MJ, Hellstrom PT, Jonsson MA, Runnerstam M, Silander HC, BenMenachem E. Cognitionenhancing impact of vagus nerve stimula tion in sufferers with Alzheimer’s illness: a pilot study.IFN-alpha 1/IFNA1 Protein custom synthesis J Clin Psychiatr. 2002;63:972sirtuininhibitor0. 28. Hiraki T, Baker W, Greenberg JH. Effect of vagus nerve stimulation for the duration of transient focal cerebral ischemia on chronic outcome in rats.Lumican/LUM Protein supplier J Neurosci Res. 2012;90:887sirtuininhibitor4.PMID:24318587 29. Sun Z, Baker W, Hiraki T, Greenberg JH. The effect of proper vagus nerve stimulation on focal cerebral ischemia: an experimental study within the rat. Brain Stimul. 2012;5:1sirtuininhibitor0. 30. Ay I, Lu J, Ay H, Gregory Sorensen A. Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia. Neurosci Lett. 2009;459:147sirtuininhibitor1.31. Ay I, Napadow V, Ay H. Electrical stimulation of the vagus nerve der matome within the external ear is protective in rat cerebral ischemia. Brain Stimul. 2015;8:7sirtuininhibitor2. 32. Tracey KJ. Physiology and immunology of the cholinergic antiinflamma tory pathway. J Clin Invest. 2007;117:289sirtuininhibitor6. 33. Zagon A, Kemeny AA. Slow hyperpolarization in cortical neurons: a pos sible mechanism behind vagus nerve simulation therapy for refractory epilepsysirtuininhibitor Epilepsia. 2000;41:1382.