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A, units Norepinephrine infusion on admission, N ( ) Fluid infusion before inclusion, median (IQR) Crystalloids (NaCl 0.9 ), ml Colloids, ml Time from brain injury to inclusion (hours) median (IQR) Biological status upon inclusion Hyperchloraemic acidosis, N ( ) Osmolarity (mOsm/L), median (IQR) Natraemia (mmol/L), median (IQR) Chloraemia (mmol/L), median (IQR) Kalemia (mmol/L), median (IQR) Ionized calcaemia (mmol/L), median (IQR) Magnesemia (mmol/L), median (IQR) Phosphoremia (mmol/L), median (IQR) Lactataemia (mmol/L), median (IQR) Azotaemia (mol/L), median (IQR) Albuminaemia (g/L), median (IQR) pH, median (IQR) SID (mmol/L), median (IQR)aIntention-to-treat population Saline (N = 21) 51 (25 – 68) 15 (71) 19 (90) 2 (ten) 8 (7 – 9) 9 (43) 2 (10) 4 (19) 3 (14) eight (38) 1000 (500 -1000) 0 (0 – 500) five (three – 7) four (19) 303 (295 – 319) 140 (138-142) 106 (104 – 110) 3.6 (three.4 – 3.9) 1.ten (1.07 – 1.14) 0.86 (0.72 – 0.95) 0.86 (0.67 – 1.07) 1.four (1.1 – two.1) 66 (56-73) 36 (32 – 41) 7.38 (7.33 – 7.44) 39 (35 – 42) Balanced (N = 20) 49 (26 – 75) 17 (85) 18 (90) 2 (ten) 7 (six – 9) four (20) 2 (ten) three (15) 0 7 (35) 1000 (500 – 1500) 0 (0 – 500) five (four – 12) two (10) 302 (296 – 319) 139 (137-141) 106 (101 – 107) 3.7 (three.5 – 4.1) 1.11 (1.07 – 1.18) 0.81 (0.75 – 0.88) 0.85 (0.74 – 1.14) 1.7 (1.1 – 2.7) 67 (58-71) 37 (34 – 39) 7.39 (7.32 – 7.45) 39 (39 – 41)TBI sufferers Saline (N = 18) 47 (28-57) 13 (72) / 7 (6-8) 8 (44) 0 four (22) 3 (17) 7 (39) 500 (500 -1000) 0 (0 – 500) four (3-6) 4 (22) 306 (299-328) 140 (138-141) 106 (104-111) three.7 (3.4-3.9) 1.10 (1.08-1.12) 0.82 (0.76-0.92) 0.88 (0.70-1.10) 1.5 (1.2-2.two) 65 (56-72) 34 (32-41) 7.36 (7.31-7.41) 40 (37-41) Balanced (N = 18) 49 (27-77) 16 (89) / 7 (6-8) 4 (22) 0 3 (17) 0 7 (39) 1000 (500 -1500) 0 (0 – 500) 5 (4-6) two (11) 306 (300-319) 139 (137-141) 106 (100-107) three.7 (3.5-4.1) 1.11 (1.06-1.18) 0.83 (0.73-0.92) 0.82 (0.73-1.13) two.0 (1.1-2.7) 67 (60-71) 36 (34-39) 7.39 (7.31-7.45) 39 (37-41)IQR: interquartile range; TBI: traumatic brain injury; Powerful Ion Difference (SID) = (Na + K + Ca + Mg) – (Cl + lactate).Ridinilazole Table 3 Fluid administration within the very first 48 hoursMedian (IQR) Saline group (N = 20) Na administration (mmol) Cl administration (mmol) Crystalloids (ml) H0 to H48 H0 to H48 H0 to H6 H6 to H24 H24 to H48 H0 to H48 Hydroxyethyl starch solutions (ml) H0 to H6 H6 to H24 H24 to H48 H0 to H48 918 (689 to 1,148) 918 (689 to 1,148) 2,000 (1,000 to two,000) 2,000 (1,500 to two,000) 2,000 (1,500 to two,000) five,000 (4,500 to six,000) 0 (0 to 500) 0 (0 to 500) 0 (0 to 0) 500 (0 to 1,500) Balanced group (N = 20) 840 (630 to 1,050) 744 (572 to 952) 1,000 (500 to 2,000) 1,500 (1,500 to 2,000) two,000 (1,500 to 2,000) five,000 (4,000 to six,000) 0 (0 to 500) 0 (0 to 500) 500 (0 to 1,000) 1,000 (500 to 1,500) P-value 0.Carbamazepine 228 0.PMID:23996047 014 0.255 0.530 0.755 0.448 0.613 0.563 0.060 0.Roquilly et al. Crucial Care 2013, 17:R77 http://ccforum/content/17/2/RPage 7 ofFigure 2 Kaplan-Meier curves for hyperchloraemic acidosis. Hyperchloraemic acidosis was defined because the association of hyperchloraemia (108 mmol/L) with powerful ion difference (SID) (40 mmol/L). SID = (Na + K + Ca + Mg) – (Cl + lactate). Na; sodium, K; potassium; Ca: calcium; Mg: magnesium; Cl: chloride.Roquilly et al. Crucial Care 2013, 17:R77 http://ccforum/content/17/2/RPage 8 ofFigure three Time course of acid-base status within the saline group and also the balanced group. Hyperchloraemic acidosis was defined because the association of hyperchloraemia (108 mmol/L) with sturdy ion distinction (SID) 40 mmol/L. SID = (.