Product Name :
CH7233163
Description:
CH7233163 is a non-covalent ATP competitive inhibitor of EGFR-tyrosine kinase with antitumor activities against tumor with EGFR-Del19/T790M/C797S.
CAS:
Molecular Weight:
669.72
Formula:
C31H34F3N9O3S
Chemical Name:
N-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-(2, 2, 2-trifluoroethoxy)pyrido[4, 3-b]indol-3-amine
Smiles :
CN1CCN(CC1)C1=CC2=C(C(=C1)OCC(F)(F)F)C1=CN=C(C=C1N2C(C)C)NC1=CC=NC(=N1)C1C=NN(C=1)S(=O)(=O)C1CC1
InChiKey:
KMBMYNDPNVGEFI-UHFFFAOYSA-N
InChi :
InChI=1S/C31H34F3N9O3S/c1-19(2)43-24-14-28(38-27-6-7-35-30(39-27)20-15-37-42(17-20)47(44,45)22-4-5-22)36-16-23(24)29-25(43)12-21(41-10-8-40(3)9-11-41)13-26(29)46-18-31(32,33)34/h6-7,12-17,19,22H,4-5,8-11,18H2,1-3H3,(H,35,36,38,39)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Asfotase alfa} medchemexpress|{Asfotase alfa} Technical Information|{Asfotase alfa} Description|{Asfotase alfa} manufacturer|{Asfotase alfa} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CH7233163 is a non-covalent ATP competitive inhibitor of EGFR-tyrosine kinase with antitumor activities against tumor with EGFR-Del19/T790M/C797S.|Product information|Molecular Weight: 669.72|Formula: C31H34F3N9O3S|Chemical Name: N-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-(2, 2, 2-trifluoroethoxy)pyrido[4, 3-b]indol-3-amine|Smiles: CN1CCN(CC1)C1=CC2=C(C(=C1)OCC(F)(F)F)C1=CN=C(C=C1N2C(C)C)NC1=CC=NC(=N1)C1C=NN(C=1)S(=O)(=O)C1CC1|InChiKey: KMBMYNDPNVGEFI-UHFFFAOYSA-N|InChi: InChI=1S/C31H34F3N9O3S/c1-19(2)43-24-14-28(38-27-6-7-35-30(39-27)20-15-37-42(17-20)47(44,45)22-4-5-22)36-16-23(24)29-25(43)12-21(41-10-8-40(3)9-11-41)13-26(29)46-18-31(32,33)34/h6-7,12-17,19,22H,4-5,8-11,18H2,1-3H3,(H,35,36,38,39)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).{{Tarextumab} medchemexpress|{Tarextumab} Notch|{Tarextumab} Technical Information|{Tarextumab} Description|{Tarextumab} custom synthesis|{Tarextumab} Epigenetics} DMSO: 100 mg/mL(149.PMID:28440459 31 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CH7233163 shows potent antitumor activities against tumor with EGFR-Del19/T790M/C797S in vitro. CH7233163 potently inhibits the proliferation of Del19/T790M/C797S_NIH3T3 cells with IC50 of 20 nmol/L. CH7233163 potently and dose-dependently blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 can inhibit Del19/T790M/C797S signaling.|In Vivo:|Pharmacodynamic study is performed using Del19/T790M/C797S_NIH3T3 xenografted tumors in mice. CH7233163 clearly inhibits EGFR phosphorylation after oral administration and potent tumor regression is observed. CH7233163 has potent therapeutic efficacy against tumors with EGFR-Del19/T790M/C797S in vivo.|Products are for research use only. Not for human use.|